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La inhibición de la síntesis de prostaglandinas conduce a una secreción excesiva de ácido y Inflamación de la mucosa gástrica y duodenal. Existen diferentes versiones de COX. TIMONEL en el estómago y en la sangre, donde la síntesis de tromboxano da como resultado la agregación plaquetaria. TIMONEL se han desarrollado que son COX selectivos Es probable que cause efectos secundarios gastrointestinales. Sin embargo, se han asociado con mayor riesgo de enfermedad tromboembólica y reacciones cutáneas graves. Esto llevó a la retirada de rofecoxib en octubre para pacientes con alto riesgo de desarrollar efectos secundarios gastrointestinales.

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